Data is rapidly emerging in the treatment of locally advanced GI cancers. Issues regarding optimal radiation dose, use of radiation, use of immunotherapy and sequence have all been evaluated in phase III trial recently and have direct relevance to practice now. In this educational session we will evaluate: Esophageal cancer- role of adjuvant immunotherapy, dose escalation in inoperable cancers Pancreatic cancer- the role of preoperative radiation in borderline resectable pancreatic cancer Rectal cancer- Total neoadjuvant therapy and non-operative management.
This session will outline the current standard of care options and new data regarding the treatment of lower gastrointestinal malignancies. First we will discuss the treatment of locally advanced rectal cancer focusing on the role of radiation in the multidisciplinary treatment of this disease. Data from randomized trials presented at ASCO 2020 will be highlighted as well the ASTRO clinical practice guidelines for rectal cancer published in January/February 2021. Special topics of clinical interest will be discussed including selective omission of radiation therapy for low risk patients and non-operative management for patients with a complete clinical response after radiation. Finally, we will discuss the role of chemoradiation in the definitive treatment of anal squamous cell carcinoma as well as the current cooperative group trials in this space.
The meeting is designed to meet the interests of practicing radiation oncologists, radiation oncology residents, medical and clinical physicists, nurses and all other health professionals involved in the field of radiation oncology.
Upon completion of this activity, participants should be able to do the following:
- Recognize appropriate radiation dose recommendations for non-operative management of esophageal cancer.
- Outline the data and limitations of studies evaluating neoadjuvant radiation for borderline resectable pancreatic cancer.
- Discuss the data supporting total neoadjuvant therapy for rectal cancer, and its relevance to non-operative management.
- Discuss and implement appropriate radiation options for a patient with locally advanced rectal adenocarcinoma.
- Discuss controversial topics such as omission of surgery and omission of radiation for patients with locally advanced rectal adenocarcinoma.
- Outline standard of care chemoradiation for patients with anal squamous cell carcinoma.
Theodore Hong, MD is employed by Massachusetts General Hospital and has no financial relationships with a commercial interest.
Emma Holiday, MD is employed by MD Anderson Cancer Center and has no financial relationships with a commercial interest.
All relevant relationships have been mitigated.
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council of Continuing Medical Education to provide continuing education to physicians.
ASTRO is awarded Deemed Status by the American Board of Radiology to provide SA-CME as part of Part II Maintenance of Certification.
- 1.50 AMA PRA Category 1 Credit™The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this for a maximum of 1.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.50 Certificate of AttendanceThis activity was designated for 1.50 AMA PRA Category 1 Credit™.