The role of radiotherapy in the management of benign diseases is ever expanding. Non-malignant entities of the head and neck are particularly complex and represent therapeutic challenges given the potential for treatment-associated morbidities.

Cancer treatment guidelines are drafted to ensure appropriate use of existing evidence and promote safe practice. While guidelines strive to keep pace with research and new technology, they often don’t address the ground level situation in community practice especially for LMIC.

While best known for its use in cancer, radiotherapy (RT) can be used as a successful treatment for several nonmalignant diseases. Nonetheless, the use of non-oncological RT is uncommon, and its utilization varies from country to country.

The activity gives an overview of irradiation of benign diseases. The worldwide unique evidence-based S2-guideline of the German Society for Radiation Oncology (DEGRO) that has been translated into English is also presented.

Although radiotherapy is a well-established treatment modality for both solid and liquid tumors, its utility in the management of benign diseases remains poorly elucidated. In general, oncologists and non-oncologic specialists in the U.S.