This session explores the role of Low Dose Radiotherapy (LDRT) in treating osteoarthritis (OA), a prevalent and debilitating condition affecting millions worldwide. Despite its widespread use in Europe, LDRT remains underutilized in the United States. Recent international studies have demonstrated significant improvements in pain relief and mobility for OA patients treated with LDRT, highlighting its potential as a cost-effective, non-invasive alternative to traditional therapies. The session may include educational discussions of the pathophysiology of OA and the background of the current treatment landscape of OA, emphasizing the limitations of existing therapies. The session can include a radiobiology focus on the anti-inflammatory mechanisms of low-dose radiotherapy, as well as delve into the historical and modern applications of LDRT, examining and reviewing recent clinical evidence that supports its efficacy and safety. The discussion addresses the controversies surrounding LDRT, including the potential risk of secondary malignancies, and provide guidance on treatment planning, including dose fractionation and energy considerations. Attendees will gain insights into the benefits of integrating LDRT into OA management protocols and explore future research directions necessary to solidify its role in clinical practice. This session aims to foster a renewed interest in LDRT among U.S. practitioners and encourage collaborative efforts to re-evaluate its application in benign musculoskeletal disorders.