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The Evolution of Cancer Within a Patient: Tumor Phylogenetics and Implications for Local Therapy
Tumor phylogenetics (or cancer phylogenetics) is the scientific method used to consider cancer biology through the lens of computational evolutionary biology. This method, also known as phylogenetic tree inference, attempts to understand how genetic changes in primary and secondary tumors evolve over time and in response to cancer therapy and environmental stress. This activity occurs in three parts and is targeted to interested clinicians and radiation biologists. The first speaker, Dr. J. Nick Fisk, describes the basics of phylogenetic algorithms and the current state of knowledge, drawing on their work with EGFR driven lung cancer and the characterization of small renal masses. The second speaker, Dr. Jacob Scott, discusses the concept of collateral sensitivity and its implications for the combination of radiation and systemic therapy. Finally, Dr. James Yu discusses the theoretical implications of this work for oligometastatic disease. This activity was created by ASTRO Science Education and Program Development (SEPD) Committee members and reflects the inclusion of scientific content and new scientific advances in the field.
Topics:
- On the Origin of Tumors: Tumor Phylogenetics and You
J. Nicholas Fisk, PhD - Tumor Collateral Sensitivity and Relevance to Radiation Oncology
Jacob Gardinier Scott, MD, PhD - Clinical Implications of Tumor Phylogeny
James B. Yu, MD, MHS, FASTRO - Q and A
James B. Yu, MD, FASTRO, MHS - Moderator
Full Panel
This activity is available from May 20, 2025, through 11:59 p.m. Eastern time on May 19, 2027.
The content was originally presented and recorded at the 2024 ASTRO Annual Meeting.
Target Audience
The activity is designed to meet the interests of medical oncologists, radiation oncologists, surgeons, pathologists, radiation biologists and residents.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Explain the concept of tumor phylogeny.
- Identify potential implications of tumor phylogenetic research for clinical radiation oncology in the context of oligometastatic disease.
- James B. Yu, MD, MHS, FASTRO, is employed by St. Francis Hospital and Connecticut Radiation Oncology. Dr. Yu receives grant/research funding and honoraria from Boston Scientific and Pfizer/Myovant. Dr. Yu owns stock in Modifi Bio. Dr. Yu serves as Editor-in-Chief of JNCI Cancer Spectrum: Oxford University Press.
- Jacob Gardinier Scott, MD, PhD, is employed by Taussig Cancer Center, Cleveland Clinic. Dr. Scott receives compensation/payment from Resistance Bio, Empyrean Medical Systems, Vironexis and Skincure Oncology. Dr. Scott is Co-founder and an investor of Cvergenx. Dr. Scott has ownership equity in Cvergenx, Resistance Bio, Vironexis and Empyrean Medical Systems.
- J. Nicholas Fisk, PhD, is employed by the University of Rhode Island. Dr. Fisk serves an uncompensated role as a faculty member for the Brown Center for Clinical Cancer Informatics and Data Science.
The person(s) above served as the developer(s) of this activity. Additionally, the ASTRO Education Committee had control over the content of this activity. All relevant financial relationships have been mitigated.
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Available Credit
- 1.00 AMA PRA Category 1 Credit™The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Enduring material for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.00 Certificate of AttendanceThis activity was designated for 1.00 AMA PRA Category 1 Credit™.
Price
Course Fees:
ASTRO members must log in to the ASTRO website to view and receive the member rate.
- Nonmember: $149
- Member: $99
- Member-in-Training: $49
- Student/Graduate Student/PGY-1 Member: $49
- Postdoctoral Fellow Member: $49
If you are an ASTRO member from a low or lower-middle income country, as identified by the World Bank, you can receive a 50% discount off your corresponding registration for this activity. Please email [email protected] to inquire about the discount.
Policies:
No refunds, extensions, or substitutions will be made for those participants who, for any reason, have not completed the activity by the expiration date.
Participants using ASTRO Academy activities to satisfy the requirement of a Continuing Certification (MOC) program should verify the credit number and type and availability dates of any activity before making a purchase. No refunds, extensions, or substitutions will be made for participants who have purchased activities that do not align with their MOC requirement.
The activity and its materials will only be available on the ASTRO website until May 19, 2027, regardless of purchase date. At the expiration of the activity, participants will no longer have access to the activity or its materials. ASTRO reserves the right to remove an activity before its expiration date.
Required Hardware/software
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