Historically, the management of lymph node positive prostate cancer was limited to androgen deprivation therapy, but increasing data now support the use of multimodality therapy. As treatment options have expanded, patient-centered decision making has become increasingly complicated. Education is needed to help clinicians provide patients with the most up-to-date information regarding the impact of various management strategies on treatment efficacy and quality of life.  

This course involves case-based presentations with expert speakers to review the various treatment options for lymph node positive prostate cancer, including radical prostatectomy, androgen deprivation therapy, and external beam radiotherapy. The role of the radiation oncologist in the workup of patients with node-positive prostate cancer is reviewed (including PSMA PET scans), along with a discussion on optimizing patient selection and treatment techniques. Post-operative management of patients with pathologic lymph node positive disease is reviewed in detail, as well as the concurrent use of systemic and radiation therapy for patients with clinically staged N1 disease. Each therapeutic modality will be discussed in the context of recently published data, ongoing clinical trials, and future directions, with a patient-centered focus.

Topics:

1. Introduction and Case Presentation
   Rahul D. Tendulkar, MD, FASTRO
2. Post-Operative Therapy for Pathologic Node Positive Prostate Cancer
   Leslie K. Ballas, MD
3. Optimizing Multimodality Therapy for Clinically Node Positive Prostate Cancer
   Omar Y. Mian, MD, PhD
4. Modern Systemic Therapy for Advanced Prostate Cancer
   Hala Borno, MD
5. Q and A
   Full Panel

This activity is available from May 14, 2024, through 11:59 p.m. Eastern time on May 13, 2026. 

This activity was originally recorded at the 2023 ASTRO Annual Meeting.