Breast
This session provides a global overview of breast radiotherapy indications, approaches and techniques, informed by the latest clinical trials and relevant research. By the completion of the session, attendees should be able to identify which patients are suitable for ultrahypofractionated radiation therapy, accelerated partial breast irradiation, omission of radiation therapy, and current indications for postmastectomy radiation therapy/comprehensive regional nodal irradiation. Particular emphasis is placed on risk stratification using tumor biology/multi-gene assays and on modern radiation techniques (concomitant boost, volumetric modulated arc radiotherapy, protons).
Target Audience
The meeting is designed to meet the interests of practicing radiation oncologists, radiation oncology residents, medical and clinical physicists, radiation therapists, radiation dosimetrists, nurses and all other health professionals involved in the field of radiation oncology.
Learning Objectives
Upon completion of this activity, participants should be able to do the following:
- Describe standard and hypofractionated whole-breast irradiation regimens, including conventional (50 Gy in 25 fractions), moderate hypofractionation (40 Gy in 15 fractions), and ultra-hypofractionation (26 Gy in 5 fractions).
- Explain clinical factors influencing the choice of fractionation schedule.
- Identify appropriate candidates for omission of radiation therapy after lumpectomy.
- Identify patient and tumor characteristics that warrant a tumor bed boost (e.g., age ≤50, high-grade tumors, close or positive margins, lymphovascular invasion).
- Discuss available lumpectomy cavity boost techniques.
- Define eligibility criteria for APBI based on ASTRO guidelines.
- List absolute and conditional indications for PMRT after upfront surgery and after neoadjuvant therapy.
- Explain scenarios where PMRT may be omitted or limited.
- Describe recommended target volumes (chest wall and regional nodes) and preferred fractionation schedules.
Moderator
- Megan E. Daly, MD, University of California Irvine, Chao Family Comprehensive Cancer Center
Speaker
- Jose G. Bazan, MD, MS, City of Hope Comprehensive Cancer Center
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Available Credit
- 1.75 AMA PRA Category 1 Credit™
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this for a maximum of 1.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.75 Certificate of AttendanceThis activity was designated for 1.75 AMA PRA Category 1 Credit™.

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