This session will discuss optimal evaluation and treatment of patients with HPV-positive oropharynx cancer. In January 2018, AJCC 8 became the new staging system, with major differences for HPV-positive oropharynx cancers; the new staging, and its implications, will be discussed. The session will review the best practices for patient evaluation and evidence-based (and guideline-based) management of HPV-positive cancers in 2018. The expected prognosis and toxicity patterns will be reviewed, in addition to their management.  Current clinical trials looking at treatment de-escalation strategies will also be reviewed, with recommendations on what should be incorporated into practice now on- and off-protocol. The indications for chemoradiation versus radiation alone, the optimal treatment in the postoperative setting after transoral robotic surgery (TORS), and contouring recommendations will be discussed with an emphasis on maximizing outcomes and reducing treatment related toxicity. Didactic information will be strengthened with case-based discussions and vignettes to illustrate real-world implications of these decisions and recommendations.