This activity explores the use of repeat radiation for intra-cranial neoplasms. Radiation is the primary management modality for the treatment of a number of intracranial pathologies and the initial treatment is well studied and relatively standardized across the specialty. However, in the setting of recurrent disease, in a wide range of conditions, there is value of further radiation that currently is likely underutilized, but can benefit patients. This spans high grade malignant brain tumors such as glioblastoma as well as low grade primary brain tumors. Additionally, the management of meningioma can be challenging and the panel discusses treatment strategies including emerging infusional radiopharmaceuticals. The management of brain metastases, as the most common intracranial malignancy, is explored in the setting of re-irradiation. The panel explores the gamut of technologies, including protons, in the presentation. Finally, the panel discusses strategies and techniques to minimize risk as well as interventions to help manage potential toxicity.