Salvage Therapy for Isolated Local-Regional Breast Cancer Recurrence

As breast cancer survivorship improves due to advances in multimodality treatment, the number of patients at risk for local-regional recurrence is rising. Radiotherapy is a key component of initial treatment, but reirradiation has traditionally been approached with caution due to concerns about serious toxicities from retreatment. However, emerging evidence suggests that select patients with recurrent breast cancer may benefit from reirradiation, safely achieving better locoregional control. This evolving data is reshaping clinical practice and expanding salvage treatment options. Additionally, the growing array of systemic therapies enhances the potential for successful management of recurrent disease. This review critically examines current reirradiation strategies, systemic therapy options, ongoing research, and practical considerations for treatment delivery in recurrent breast cancer.

Please visit LINK to read the related journal article online. 

This activity is available from September 23, 2025, through 11:59 p.m. Eastern time on September 22, 2027.

This article is from the International Journal of Radiation Oncology•Biology•Physics (Red Journal).

Target Audience

This course is designed to meet the interest of radiation oncologists and radiation oncology residents.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Understand the evolving role of reirradiation in the management of recurrent breast cancer, including its risks, benefits, and clinical indications.
  • Explore the integration of systemic therapies with radiation in salvage treatment approaches to optimize outcomes for patients with locoregional recurrence.
  • Evaluate current evidence and ongoing studies that can guide decision-making in the multidisciplinary management of recurrent breast cancer.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™

    The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • 1.00 Certificate of Attendance
    This activity was designated for 1.00 AMA PRA Category 1 Credit™.
Course opens: 
09/23/2025
Course expires: 
09/22/2027
Cost:
$49.00
Rating: 
0

Sue Yom, MD, PhD, FASTRO is employed by the University of California and receives compensation from Bristol-Myers Squibb, EMD Serono, Nanobiotx and Elsevier as well as ownership/investment in Springer and Up To Date.

The person(s) above served as the developer(s) of this activity. Additionally, ASTRO Education Committee had control over the content of this activity.

All relevant relationships have been mitigated.

The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™

    The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • 1.00 Certificate of Attendance
    This activity was designated for 1.00 AMA PRA Category 1 Credit™.

Price

Cost:
$49.00
Please login or register to take this course.

Course Fees:
ASTRO members must log in to the ASTRO website to view and receive the discounted member rate.

  • Nonmember: $49
  • Member: $0


Policies:
No refunds, extensions, or substitutions will be made for those participants who, for any reason, have not completed the course by the end of the qualification date. The qualification date for each course is listed in the course catalog on the ASTRO website under availability.

Participants using ASTRO's online courses to satisfy the requirement of a Maintenance of Certification (MOC) program should verify the number, type and availability dates of any course before making a purchase. No refunds, extensions, or substitutions will be made for participants who have purchased courses that do not align with their MOC requirement.

The activity and its materials will only be available on the ASTRO website until September 22, 2027, regardless of purchase date. At the expiration of the activity, participants will no longer have access to the activity or its materials. ASTRO reserves the right to remove an activity before its expiration date.

 

Required Hardware/software

One of the two latest versions of Google Chrome, Mozilla Firefox, Internet Explorer or Safari.