A Randomized Study of Consolidation Chemoradiation (CTRT) versus Observation after first line chemotherapy (CT) in Advanced Gall Bladder Cancers (GBC): Race-GB Study

Management of unresectable gall bladder cancer (GBC) is challenging, and it can be especially so in Low-to-Middle Income Countries (LMIC), as <50% of patients complete the standard 6 cycles of CT.  This article presents the results of a single center, open label, randomized trial evaluating consolidation chemoradiation (CTRT) versus observation in a LMIC center for patients with unresectable gall bladder cancer (GBC) who completed and responded to 4 cycles of chemotherapy.  The endpoint was overall survival (OS).  

A total of 135 patients were randomized into two groups (67 – observation, 68 – CTRT). RT consisted of 3DRT to the GBC and lymphatics (45Gy in 25fx), followed by a boost to GBC (9Gy in 5fx).  The actual median OS from the time of
recruitment was 7 months (95%CI 6.114 to 7.88) in the observation arm versus 13 months (95% CI 11.13 months to 14.84 months) in the CTRT arm.

Please visit https://www.redjournal.org/article/S0360-3016(24)03706-4/fulltext to read the related journal article online. 

This activity is available from April 14, 2025, through 11:59 p.m. Eastern time on April 13, 2027.

This article is from the May  2025 issue of the International Journal of Radiation Oncology•Biology•Physics (Red Journal).

Target Audience

This course is designed to meet the interest of radiation oncologists and radiation oncology residents.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the additional challenges for treatment of unresectable gall bladder cancers (GBC) in low-to-middle income countries (LMIC).
  • Summarize the results of a randomized trial (single center, LMIC) evaluating consolidation chemoradiation versus observation for patients with unresectable GBC with overall survival as the endpoint.

 

 

Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
    The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Course opens: 
04/14/2025
Course expires: 
04/13/2027
Cost:
$49.00
Rating: 
0

Sue Yom, MD, PhD, FASTRO is employed by the University of California and receives compensation from Bristol-Myers Squibb, EMD Serono, Nanobiotx and Elsevier as well as ownership/investment in Springer and Up To Date.

The person(s) above served as the developer(s) of this activity. Additionally, ASTRO Education Committee had control over the content of this activity.

All relevant relationships have been mitigated.

Disclosure link: 
ASTRO Education Committee

The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
    The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Price

Cost:
$49.00
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Course Fees:
ASTRO members must log in to the ASTRO website to view and receive the discounted member rate.

  • Nonmember: $49
  • Member: $0


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The activity and its materials will only be available on the ASTRO website until April 13, 2027, regardless of purchase date. At the expiration of the activity, participants will no longer have access to the activity or its materials. ASTRO reserves the right to remove an activity before its expiration date.

 

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