This activity focuses on the multidisciplinary care of liver and pancreatic cancer highlighting the role of radiation therapy. One talk discusses the role of radiation therapy in the hepatocellular carcinoma, focusing on evidence supporting the use of radiotherapy across multiple settings: definitive treatment in early stage, combination therapy in advanced disease, bridge or downstaging to transplant and for palliation. Radiation Oncologists sometimes do not fully engage in the multidisciplinary discussion of these patients with complex and challenging malignancies due to unfamiliarity with the indications for radiation therapy, the integration of RT in the multidisciplinary care and/or due to lack of familiarity in planning and delivery of moving and changing target volumes and organ at risk. One of the talks discusses promising data on the emerging role of dose escalated radiation therapy in the definitive management of locally advanced pancreatic cancer, the use of elective volumes for pancreas SBRT, and also provides learners practical advice on how this can be safely delivered. The third talk discusses the complex imaging changes that occur in the liver after SBRT or hypofractionated radiotherapy. Radiation Oncologists must have this knowledge to discuss with their radiology colleagues to appropriately differentiate what are expected post treatment changes and what may be signs of progression. This session addresses these challenges.