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ForwardPre-operative Radiotherapy in Locally Advanced Breast Cancer: A Narrative Review
This activity reviews the evolving role of pre‑operative (neoadjuvant) radiation therapy (preRT) in the management of locally advanced breast cancer (LABC). It summarizes historical and contemporary evidence on preRT alone and in combination with systemic therapies, highlights its impact on surgical outcomes and breast reconstruction, and explores emerging therapeutic innovations—including immunotherapy and advanced radiation techniques. The content outlines clinical rationale, treatment outcomes, toxicity considerations, and future research directions in this rapidly developing field.
This activity is available from February 5, 2026, through 11:59 p.m. Eastern time on February 4, 2028.
This article is from the International Journal of Radiation Oncology•Biology•Physics (Red Journal).
Target Audience
This course is designed to meet the interest of radiation oncologists, surgeons and radiation oncology residents.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the clinical rationale for implementing pre‑operative radiation therapy in LABC.
- Evaluate the impact of preRT on surgical feasibility and breast reconstruction outcomes.
- Summarize historical and current evidence evaluating outcomes of preRT alone and in combination with systemic therapies.
Sue Yom, MD, PhD, FASTRO is employed by the University of California and receives compensation from Bristol-Myers Squibb, EMD Serono, Nanobiotx and Elsevier as well as ownership/investment in Springer and Up To Date.
The person(s) above served as the developer(s) of this activity. Additionally, ASTRO Education Committee had control over the content of this activity.
All relevant relationships have been mitigated.
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Available Credit
- 1.00 AMA PRA Category 1 Credit™
The American Society for Radiation Oncology (ASTRO) is accredited by the Accreditation Council for Continuing Medical Education for physicians. ASTRO designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.00 Certificate of AttendanceThis activity was designated for 1.00 AMA PRA Category 1 Credit™.
Price
Course Fees:
ASTRO members must log in to the ASTRO website to view and receive the discounted member rate.
- Nonmember: $49
- Member: $0
Policies:
No refunds, extensions, or substitutions will be made for those participants who, for any reason, have not completed the course by the end of the qualification date. The qualification date for each course is listed in the course catalog on the ASTRO website under availability.
Participants using ASTRO's online courses to satisfy the requirement of a Maintenance of Certification (MOC) program should verify the number, type and availability dates of any course before making a purchase. No refunds, extensions, or substitutions will be made for participants who have purchased courses that do not align with their MOC requirement.
The activity and its materials will only be available on the ASTRO website until February 4, 2028, regardless of purchase date. At the expiration of the activity, participants will no longer have access to the activity or its materials. ASTRO reserves the right to remove an activity before its expiration date.
Required Hardware/software
One of the two latest versions of Google Chrome, Mozilla Firefox, Internet Explorer or Safari.