This webinar will provide a practical medical physics perspective on implementing SBRT for polymetastatic disease. Key topics will include CT simulation and imaging strategies, motion management, multi-isocenter treatment planning, composite plan evaluation, and treatment delivery considerations. Drawing on practical examples and lessons learned
from the ARREST and ARREST-2 trials, the presentation will highlight how structured multidisciplinary communication, quality assurance checkpoints, and adaptive decision-making can support safe, efficient, and high-quality treatment delivery.
The presentation will also review the clinical rationale for extending SABR to polymetastatic disease, examine emerging evidence from the ARREST studies, and discuss practical
considerations for safely implementing these complex treatments. Topics will include patient selection based on technical feasibility rather than lesion count alone, multidisciplinary workflow, simulation and treatment delivery strategies, organ-at-risk–driven decision making, and planning approaches that enable treatment of numerous metastases while maintaining safety. Attendees will gain practical insights into how comprehensive SABR can be incorporated into clinical practice and how lessons from the ARREST program are informing the ongoing international ARREST-2 trial.